PKC-412|cas 120685-11-2|buy|Price|from DC Chemicalsicals

PKC-412|cas 120685-11-2|buy|Price|from DC Chemicalsicals

DC Chemicals supplies: PKC-412,cas: 120685-11-2,Catalog: DC7634,In stock.

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Product name: PKC-412, Synonyms: Midostaurin, CGP-41251, PKC-412, Cgp 41251, CHEBI:63452, PKC 412, N-Benzoylstaurosporine, staurosporine, N-benzoyl-, SureCN8295379, cas: 120685-11-2, MW:  570.6371 , Molecule Formula: C35H30N4O4

PKC-412, cas: 120685-11-2, From DC Chemicals. PKC-412 is a broad spectrum protein kinase inhibitor. Inhibits conventional PKC isoforms (α, β, γ), PDFRβ, VEGFR2, Syk, PKCη, Flk-1, Flt3, Cdk1/B, PKA, c-Kit, c-Fgr, c-Src, VEGFR1 and EGFR. Displays potent antitumor activity.

PKC 412 is a cell-permeable, reversible inhibitor of several serine/threonine and tyrosine kinases, including conventional PKC iso Forms (α, β, and γ), Syk, Flk-1, Akt, PKA, c-Kit, C-Fgr, c-Src, FLT3, PDFRβ, VEGFR1, and VEGFR2 with IC50 values ranging from 80-500 nM.It also upregulates the expression of endothelial nitric oxide synthase (eNOS) in mice.PKC 412 inhibits growth or induces apoptosis in many cancer cell types, blocks angiogenesis in tumors, and sensitizes cancer cells to ionizing radiation, supporting its use in cancer therapy.For the detailed information of PKC-412, the solubility of PKC-412 in water, the solubility of PKC-412 in DMSO, the solubility of PKC-412 in PBS buffer, the animal experiment (test) of  PKC-412, the cell expriment (test) of PKC-412, the in vivo, in vitro and clinical trial test of PKC-412, the EC50, IC50,and Affinity of PKC-412, Please contact DC Chemicals.