PFI-3|cas |buy|Price|from DC Chemicalsicals

PFI-3|cas |buy|Price|from DC Chemicalsicals

DC Chemicals supplies: PFI-3,cas: ,Catalog: DC7649,In stock.

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Product name: PFI-3, Synonyms: PFI3, PFI 3, cas: , MW: 321.37, Molecule Formula: C19H19N3O2

PFI-3, cas: , From DC Chemicals. PFI-3 is a novel potent, selective and cell permeable inhibitor of SMARCA4 and PB1(5) bromodomains with IC50 ~ 89 nM and 48 nM respectively. 

PFI-3 is a novel potent, selective and cell permeable inhibitor of SMARCA4 and PB1(5) bromodomains with IC50 ~ 89 nM and 48 nM respectively. It also inhibits SMARCA2, but has no interaction with the other sub-family branches including PB1(2-4) and a kinase panel of 36 kinases. It accelerates FRAP recovery in cells at a concentration of 1 μM. The SWI/SNF-related, Matrix-associated, Actin-dependent Regulator of Chromatin (SMARC) proteins integrate into complexes that remodel chromatin. The SMARC family A (SMARCA) members SMARCA2 (also known as BRM) and SMARCA4 (also known as BRG1) are helicases that contain structurally-related bromodomains  For binding acetylated lysine residues on target proteins. PFI-3 is a very useful chemical probe to study the key chromatin remodeling and transcription control.For the detailed information of PFI-3, the solubility of PFI-3 in water, the solubility of PFI-3 in DMSO, the solubility of PFI-3 in PBS buffer, the animal experiment (test) of  PFI-3, the cell expriment (test) of PFI-3, the in vivo, in vitro and clinical trial test of PFI-3, the EC50, IC50,and Affinity of PFI-3, Please contact DC Chemicals.