BRD73954 supplier|BRD-73954|DC Chemicals

BRD73954 supplier|BRD-73954|DC Chemicals
DC Chemicals provides BRD73954, other names: BRD-73954，BRD 73954, cas: 1440209-96-0. In stock.

Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643266；

 BRD-73954 is a biochemical inhibitor histone deacetylase cancer histone modification epigenetics gene regulation small molecule HDAC6 HDAC8.

BRD73954, other names: BRD-73954，BRD 73954, cas: 1440209-96-0, Molecule formular: C16H16N2O3, Molecule Weight: 284.3, Chemical name: N1-​hydroxy-​N3-​(2-​phenylethyl)-​1,​3-​benzenedicarboxamide

HDACs are a family of proteins with diverse roles. HDAC6 is a class IIb histone that deacetylates cytoplasmic proteins, including tubulin, heat shock protein 90, and cortactin, and has roles in cell adhesion and motility.1 HDAC8, on the other hand, is a class I histone that primarily targets nuclear proteins, including histones and cohesins, and regulates gene expression.2,3 BRD73954 is a small molecule inhibitor that potently inhibits both HDAC6 and HDAC8 (IC50s = 36 and 120 nM, respectively).4 It is at least 75-fold less effective against other HDAC isoforms.4 At 10 µM, BRD73954 treatment results in a robust increase in acetylation of α-tubulin, a known HDAC6 substrate, but not histone H3, a substrate for HDAC1, 2, and 3, in HeLa cells. For the detailed information of BRD73954, the solubility of BRD73954 in water, the solubility of BRD73954 in DMSO, the solubility of BRD73954 in PBS buffer, the animal experiment (test) of  BRD73954, the cell expriment (test) of BRD73954, the in vivo, in vitro and clinical trial test of BRD73954, the EC50, IC50,and affinity,of BRD73954, Please contact DC Chemicals.