DC Chemicals supplies: GS9973,cas: 1229208-44-9,Catalog: DC7626,In stock.
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Product name: GS9973, Synonyms: GS-9973,GS 9973, cas: 1229208-44-9, MW: 411.46, Molecule Formula: C23H21N7O
GS9973, cas: 1229208-44-9, From DC Chemicals. GS-9973 is an orally bioavailable, selective Syk inhibitor with IC50 of 7.7 nM. Phase 2.
GS-9973 shows good bidirectional permeability across Caco-2 cell monolayers in vitro. In cells, GS-9973 also shows excellent selectivity For Syk, and potently inhibits BCR-mediated activation and proliferation of B-cells as well as immune-complex-stimulated cytokine production in monocytes. The combination of idelalisib and GS-9973 synergistically inhibits CLL cell viability and further disrupts chemokine signaling. GS-9973 (1 mg/kg p.o.) shows moderate to high bioavailability in rat and dog. In a rat collagen-induced arthritis model, GS-9973 (1-10 mg/kg p.o.) significantly inhibits ankle inflammation. Moreover, GS-9973 also shows disease-modifying activity in multiple histological measurements, including inhibition of pannus Formation, cartilage damage, bone resorption, and peritosteal bone Formation with ED50 ranging from 1.2 to 3.9 mg/kg . For the detailed information of GS9973, the solubility of GS9973 in water, the solubility of GS9973 in DMSO, the solubility of GS9973 in PBS buffer, the animal experiment (test) of GS9973, the cell expriment (test) of GS9973, the in vivo, in vitro and clinical trial test of GS9973, the EC50, IC50,and Affinity of GS9973, Please contact DC Chemicals.
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