ACT058362 (Palosuran)supplier|ACT-058362|DC Chemicals

ACT058362 (Palosuran)supplier|ACT-058362|DC Chemicals
DC Chemicals provides ACT058362 (Palosuran), other names: ACT058362，ACT-058362, cas: 540769-28-6. In stock.

Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643300；

Palosuran (ACT-058362) is a new potent and specific antagonist of the human UT receptor with an IC50 of 3.6±0.2 nM.

ACT058362 (Palosuran), other names: ACT058362，ACT-058362, cas: 540769-28-6, Molecule formular: C25H30N4O2, Molecule Weight: 418.53, Chemical name: Urea, N-[2-[4-hydroxy-4-(phenylMethyl)-1-piperidinyl]ethyl]-N'-(2-Methyl-4-quinolinyl)-

Palosuran inhibited 125I-U-II binding to human UT receptors in membrane preparations from CHO cells carrying the human UT receptors almost as potently as cold U-II, with an IC50 of 3.6 ± 0.2 nM. On cells, the inhibitory binding potency of palosuran against human UT receptor was lower than on membranes (IC50 = 46.2 ± 13 nM on TE 671 cells and 86 ± 30 nM on recombinant CHO cells). Compared with the human UT receptor, the binding inhibitory potency of palosuran against the rat UT receptor was lower in membrane preparation (400-fold), as well as in cells (>120-fold) For the detailed information of ACT058362 (Palosuran), the solubility of ACT058362 (Palosuran) in water, the solubility of ACT058362 (Palosuran) in DMSO, the solubility of ACT058362 (Palosuran) in PBS buffer, the animal experiment (test) of  ACT058362 (Palosuran), the cell expriment (test) of ACT058362 (Palosuran), the in vivo, in vitro and clinical trial test of ACT058362 (Palosuran), the EC50, IC50,and affinity,of ACT058362 (Palosuran), Please contact DC Chemicals.