Ro 48-8071 fumarate supplier|Ro 488071 |DC Chemicals
DC Chemicals provides Ro 48-8071 fumarate, other names: Ro 488071 , cas: 189197-69-1. In stock.
Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643263；
Ro 48-8071 fumarate is an inhibitor of OSC(Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity.
Ro 48-8071 fumarate, other names: Ro 488071 , cas: 189197-69-1, Molecule formular: C27H31BrFNO6, Molecule Weight: 564.44, Chemical name: [4′-[6-(Allylmethylamino)hexyloxy]-4-bromo-2′-fluorobenzophenone fumarate
Ro 48-8.071 blocked human liver OSC and cholesterol synthesis in HepG2 cells in the nanomolar range; in cells it triggered the production of monooxidosqualene, dioxidosqualene, and epoxycholesterol [1]. Ro 48-8071 showed potent noncompetitive inhibition of bacterial squalene:hopene cyclase (SHC) from Alicyclobacillus acidocaldarius (IC50 = 9.0 nM, KI = 6.6 nM) and OSLC (IC50 = 40 nM, KI = 22 nM for homogeneous rat liver OSLC) [2]. Ro 48-8071 dose-dependently inhibited 17β-estradiol (E2)-induced ERα responsive luciferase activity (IC50 value, ~10 μM), under conditions that were non-toxic to the cells. Ro 48-8071 was less effective against ERβ-induced luciferase activity. Androgen receptor (AR) mediated transcriptional activity was also reduced by Ro 48-8071 [ For the detailed information of Ro 48-8071 fumarate, the solubility of Ro 48-8071 fumarate in water, the solubility of Ro 48-8071 fumarate in DMSO, the solubility of Ro 48-8071 fumarate in PBS buffer, the animal experiment (test) of Ro 48-8071 fumarate, the cell expriment (test) of Ro 48-8071 fumarate, the in vivo, in vitro and clinical trial test of Ro 48-8071 fumarate, the EC50, IC50,and affinity,of Ro 48-8071 fumarate, Please contact DC Chemicals.
没有评论:
发表评论