DC Chemicals supplies: LuAE58054,cas: 467458-02-2,Catalog: DC7583,In stock.
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Product name: LuAE58054, Synonyms: Lu AE58054 Hydrochloride, Lu AE 58054 Hydrochloride, AGN-PC-035E41, HY-14338A, CS-1359, QC-10464, Lu AE58054 Hydrochloride|467458-02-2, cas: 467458-02-2, MW: 434.830616, Molecule Formula: C20H20ClF5N2O
LuAE58054, cas 467458-02-2, Purity>98%. Best price and quality from DC Chemicals. KX1-004 is a potent small molecule inhibitor of Src-PTK as a potential protective drug for NIHL.
This orally available drug is an antagonist of the serotonin 6 (5-HT6) receptor. This receptor subtype is expressed primarily in the brain, particularly in the cerebral cortex and hippocampus, where it has been proposed to play a role in cognitive impairments associated with schizophrenia and Alzheimer's disease. The 5-HT6 receptor antagonists are thought to enhance cholinergic, glutamatergic, noradrenergic, and dopaminergic neurotransmission. Apart from some affinity For adrenergic receptors, Lu AE58054 has been reported to be highly selective over other G-protein coupled receptors. The compound enters the brain and dose-dependently reversed deficits in a rat model of cognitive impairment (Upton et al., 2008; Arnt et al., 2010). Lu AE58054 is being developed as a symptomatic adjunct to cholinesterase inhibitor treatment in Alzheimer's disease. Lu AE58054 was originally discovered by Lilly, which licensed it to the biotechnology company Saegis For the development of cognitive impairment in thinking disorders such as schizophrenia. In 2006, Saegis was acquired by Lundbeck, which in October 2013 launched a global Phase 3 program in AD. This program consists of four trials planned to enroll a total of about 3,000 patients (see company press release).For the detailed information of LuAE58054, the solubility of LuAE58054 in water, the solubility of LuAE58054 in DMSO, the solubility of LuAE58054 in PBS buffer, the animal experiment (test) of LuAE58054, the cell expriment (test) of LuAE58054, the in vivo, in vitro and clinical trial test of LuAE58054, the EC50, IC50,and Affinity of LuAE58054, Please contact DC Chemicals.
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