NSC 23766 supplier|NSC23766|DC Chemicals

NSC 23766 supplier|NSC23766|DC Chemicals
DC Chemicals provides NSC 23766, other names: NSC23766，NSC-23766, cas: 733767-34-5. In stock.

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NSC 23766 is a specific inhibitor of the binding and activation of RAC GTPase with IC50 of ~50 μM; does not inhibit the closely related targets, Cdc42 or RhoA.

NSC 23766, other names: NSC23766，NSC-23766, cas: 733767-34-5, Molecule formular: C24H35N7, Molecule Weight: 421.58, Chemical name: N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride

NSC23766 is identified to fit into a surface groove of Rac1 known to be critical for GEF specification. NSC23766 effectively inhibits Rac1 binding and activation by the Rac-specific GEF Trio or Tiam1 in a dose-dependent manner without interfering with the closely related Cdc42 or RhoA binding or activation by their respective GEFs or with Rac1 interaction with BcrGAP or effector PAK1 [1]. 50 μM NSC 23766 inhibits thrombin-induced activation of Rac1 an d Rac2 in human platelets, as well as platelet aggregation [2].  NSC23766 regulates endothelial nitric oxide synthase expression and endothelial function. 100 μM NSC23766 represses the eNOS promoter activity by 60% in bovine aortic ECs and by 30% to 35% in bEND.3 cells. Inhibition of Rac1 with NSC23766 destabilizes eNOS mRNA and shortens its half-life to 17 hours. NSC23766 dose-dependently attenuates ACh-induced relaxation of wild-type mice aortic rings  For the detailed information of NSC 23766, the solubility of NSC 23766 in water, the solubility of NSC 23766 in DMSO, the solubility of NSC 23766 in PBS buffer, the animal experiment (test) of  NSC 23766, the cell expriment (test) of NSC 23766, the in vivo, in vitro and clinical trial test of NSC 23766, the EC50, IC50,and affinity,of NSC 23766, Please contact DC Chemicals.