GSK-J4-HCL|cas 1373423-53-0(free base)|buy|Price|from DC Chemicalsicals

GSK-J4-HCL|cas 1373423-53-0(free base)|buy|Price|from DC Chemicalsicals

DC Chemicals supplies: GSK-J4-HCL,cas: 1373423-53-0(free base),Catalog: DC7654,In stock.

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Product name: GSK-J4-HCL, Synonyms: GSK J4, GSKJ4, cas: 1373423-53-0(free base), MW: 453.96, Molecule Formula: C24H27N5O2.HCl

GSK-J4-HCL, cas: 1373423-53-0(free base), From DC Chemicals. GSK J4 HCl is a cell permeable prodrug of GSK J1, which is the first selective inhibitor of the H3K27 histone demethylase JMJD3 and UTX with IC50 of 60 nM and inactive against a panel of demethylases of the JMJ family.

GSK J4 HCl is an ethyl ester derivative of the JMJD3 selective histone demethylase inhibitor GSK-J1 with an IC50 value greater than 50 μM in vitro. GSK J4 HCl is used to probe the consequences of demethylation of H3K27me3. In human primary macrophages, GSK-J4 inhibits the lipopolysaccharide-induced production of cytokines, including pro-inflammatory tumour necrosis factor (TNF). In addition, GSK-J4 prevents the lipopolysaccharide-induced loss of H3K27me3 associated with the TNF transcription start sites and blocked the recruitment of RNA polymerase II. [1]For the detailed information of GSK-J4-HCL, the solubility of GSK-J4-HCL in water, the solubility of GSK-J4-HCL in DMSO, the solubility of GSK-J4-HCL in PBS buffer, the animal experiment (test) of  GSK-J4-HCL, the cell expriment (test) of GSK-J4-HCL, the in vivo, in vitro and clinical trial test of GSK-J4-HCL, the EC50, IC50,and Affinity of GSK-J4-HCL, Please contact DC Chemicals.