DC Chemicals supplies: LGD-4033,cas: 1165910-22-4,Catalog: DC7633,In stock.
Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
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Product name: LGD-4033, Synonyms: LGD4033, 4-((R)-2-((R)-2,2,2-Trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-(trifluoromethyl)benzonitrile, cas: 1165910-22-4, MW: 338.248299 , Molecule Formula: C14H12F6N2O
LGD-4033, cas: 1165910-22-4, From DC Chemicals. LGD-4033 is a novel selective androgen receptor modulator (SARM)
Pre-clinical Modeling of LGD-4033 Efficacy: In castrated male rats,LGD-4033 increased levator ani muscle weight in a dose dependent manner when administered via continuous release osmotic minipump. Osmotic minipump dosing was utilized to mimic the long half-life observed in humans. The dose (0.3 mg/kg) corresponding to an exposure of 80 ng?hr/mLrestored muscle mass to the eugonadal level.
Predicted Human Efficacy of LGD-4033: Pre-clinical modeling suggests that activity will be observed at 80 ng?hr/mL, corresponding to a human dose of 0.5 mg. With daily dosing the anticipated therapeutic dose at steady state is 0.2 mg (allowing For 2.5 fold accumulation). Testosterone decreased from baseline values in a dose dependent manner in this single dose Phase I trial, suggesting testosterone may be a useful biomarker.For the detailed information of LGD-4033, the solubility of LGD-4033 in water, the solubility of LGD-4033 in DMSO, the solubility of LGD-4033 in PBS buffer, the animal experiment (test) of LGD-4033, the cell expriment (test) of LGD-4033, the in vivo, in vitro and clinical trial test of LGD-4033, the EC50, IC50,and Affinity of LGD-4033, Please contact DC Chemicals.
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