DC Chemicals supplies: EHT 1864,cas: 754240-09-0,Catalog: DC7639,In stock.
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Product name: EHT 1864, Synonyms: EHT-1864,EHT1864, cas: 754240-09-0, MW: 581.47, Molecule Formula: C25H29Cl2F3N2O4S
EHT 1864, cas: 754240-09-0, From DC Chemicals. EHT 1864 is a potent Rac family GTPase inhibitor with Kd of 40 nM, 50 nM, 60 nM and 250 nM for Rac1, Rac1b, Rac2 and Rac3, respectively.
EHT 1864 selectively inhibits Rac-induced lamellipodia Formation, and specifically reverses cell trans Formation induced by constitutively activated mutants of Rac1 and Tiam1. EHT 1864 strongly impaires oncogenic Ras-induced cell proliferation in NIH 3T3 cells stably expressing H-Ras(61L) protein. [1] EHT 1864 also reduces both extracellular and intracellular levels of Aβ peptides by inhibiting the γ-secretase-dependent cleavage of APP. [2] In cultured hippocampal pyramidal neurons, EHT 1864, via inhibition of Rac1, rescues the phenotype induced by Rich2 knock-down. [3] EHT 1864 (40 mg/kg i.p.) significantly reduces Abeta 40 and Abeta 42 levels in guinea pig brains. [2]For the detailed information of EHT 1864, the solubility of EHT 1864 in water, the solubility of EHT 1864 in DMSO, the solubility of EHT 1864 in PBS buffer, the animal experiment (test) of EHT 1864, the cell expriment (test) of EHT 1864, the in vivo, in vitro and clinical trial test of EHT 1864, the EC50, IC50,and Affinity of EHT 1864, Please contact DC Chemicals.
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