PF-06447475 supplier|PF06447475|DC Chemicals

PF-06447475 supplier|PF06447475|DC Chemicals
DC Chemicals provides PF-06447475, other names: PF 06447475，PF06447475, cas:  1527473-33-1. In stock.

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sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
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PF-06447475 is a highly potent, selective, brain penetrant LRRK2 inhibitor with IC0 of 3 nM/11 nM for Wt LRRK2/G2019S LRRK2 respectively.

PF-06447475, other names: PF 06447475，PF06447475, cas:  1527473-33-1, Molecule formular: C17H15N5O, Molecule Weight: 305.33, Chemical name:

PF-06447475 was sufficiently potent in the LRRK2 whole cell assay (WCA; IC50=25 nM) (pS935 end point) to warrant additional profiling. Oral administration of PF-06447475 twice daily for 15 days was well tolerated at doses up to 60 mg kg-1 day-1 (31-fold Cave,0.24h; 70-fold Cmax) with only minimal alterations in RBC parameters, electrolytes, and food consumption without concurrent effects on body weight.
 For the detailed information of PF-06447475, the solubility of PF-06447475 in water, the solubility of PF-06447475 in DMSO, the solubility of PF-06447475 in PBS buffer, the animal experiment (test) of  PF-06447475, the cell expriment (test) of PF-06447475, the in vivo, in vitro and clinical trial test of PF-06447475, the EC50, IC50,and affinity,of PF-06447475, Please contact DC Chemicals.