UMI-77 supplier|UMI77|DC Chemicals
DC Chemicals provides UMI-77, other names: UMI 77，UMI77, cas: 518303-20-3. In stock.
Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643280；
UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family.
UMI-77, other names: UMI 77，UMI77, cas: 518303-20-3, Molecule formular: C18H14BrNO5S2, Molecule Weight: 468.34, Chemical name: 2-[4-[(4-bromophenyl)sulfonylamino]-1-hydroxynaphthalen-2-yl]sulfanylacetic acid
UMI-77 effectively disrupts the interactions between BL-Noxa and cellular Mcl-1, as well as Mcl-1/Bax protein–protein interactions. [1] UMI-77 inhibits growth of pancreatic cancer cells with IC50 of 3.4, 4.4, 12.5, 16.1, and 5.5 μM for BxPC-3, Panc-1, MiaPaCa-2, AsPC-1 and Capan-2 cells, respectively. UMI-77 induced apoptosis in pancreatic cancer through activation of the intrinsic apoptotic pathway and/or Bax conformational change. For the detailed information of UMI-77, the solubility of UMI-77 in water, the solubility of UMI-77 in DMSO, the solubility of UMI-77 in PBS buffer, the animal experiment (test) of UMI-77, the cell expriment (test) of UMI-77, the in vivo, in vitro and clinical trial test of UMI-77, the EC50, IC50,and affinity,of UMI-77, Please contact DC Chemicals.
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