HPOB supplier|DC Chemicals
DC Chemicals provides HPOB, other names: , cas: 1429651-50-2. In stock.
Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643292；
HPOB is a novel selective inhibitor of HDAC6 catalytic activity in vivo and in vitro.
HPOB, other names: , cas: 1429651-50-2, Molecule formular: C17H18N2O4, Molecule Weight: 314.34, Chemical name: N-Hydroxy-4-(2-[(2-hydroxyethyl)(phenyl)amino]-2-oxoethyl)benzamide
HPOB is a potent inhibitor of histone deacetylase 6 (HDAC6; IC50 = 56 nM).1 It is at least 30-fold less effective against other HDACs.1 Through its effects on HDAC6, HPOB induces acetylation of α-tubulin but not histones.1 HPOB reduces the growth, but not the viability, of normal and transformed cells.1 It enhances the death of transformed cells as triggered by the topoisomerase II inhibitors etoposide and doxorubicin.1 HPOB enhances the cytotoxicity of the broad spectrum HDAC inhibitor SAHA (Item No. 10009929) against cancer cells in nude mice carrying an androgen-dependent CWR22 human prostate cancer xenograft. For the detailed information of HPOB, the solubility of HPOB in water, the solubility of HPOB in DMSO, the solubility of HPOB in PBS buffer, the animal experiment (test) of HPOB, the cell expriment (test) of HPOB, the in vivo, in vitro and clinical trial test of HPOB, the EC50, IC50,and affinity,of HPOB, Please contact DC Chemicals.
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