capasazepine supplier||DC Chemicals

capasazepine  supplier||DC Chemicals
DC Chemicals provides capasazepine , other names: , cas: 138977-28-3. In stock.

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Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, capsaicin; potent TRPV1 receptor antagonist with IC50 of 562 nM.

capasazepine , other names: , cas: 138977-28-3, Molecule formular: C19H21ClN2O2S, Molecule Weight: 376.9, Chemical name:   N-​[2-​(4-​Chlorophenyl)​ethyl]​-​1,3,4,5-​tetrahydro-​7,8-​dihydroxy-​2H-​2-​benzazepine-​2-​carbothioamide

Capsazepine potentiated the effect of TRAIL, as shown by its effect on intracellular esterase activity; activation of caspase-8,-9, and -3; and colony-formation assay. Capsazepine induced death receptors (DRs) DR5 and DR4, but not decoy receptors, at the transcriptional level and in a non-cell-type-specific manner [2]. Capsazepine (10 microM) reversibly reduced or abolished the current response to capsaicin (500 nM) of voltage-clamped dorsal root ganglion (DRG) neurones from rats  For the detailed information of capasazepine , the solubility of capasazepine  in water, the solubility of capasazepine  in DMSO, the solubility of capasazepine  in PBS buffer, the animal experiment (test) of  capasazepine , the cell expriment (test) of capasazepine , the in vivo, in vitro and clinical trial test of capasazepine , the EC50, IC50,and affinity,of capasazepine , Please contact DC Chemicals.