Ledipasvir supplier|GS 5885|DC Chemicals

Ledipasvir supplier|GS 5885|DC Chemicals
DC Chemicals provides Ledipasvir, other names: GS 5885，GS-5885，GS5885, cas: 1256388-51-8. In stock.

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sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
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Ledipasvir(GS5885) is an inhibitor of the hepatitis C virus NS5A protein. Ledipasvir is an experimental drug for the treatment of hepatitis C.

Ledipasvir, other names: GS 5885，GS-5885，GS5885, cas: 1256388-51-8, Molecule formular: C49H54F2N8O6, Molecule Weight: 889, Chemical name:

GS-5885 was well tolerated and resulted in median maximal reductions in HCV RNA ranging from 2.3 log(10) IU/ml (1 mg QD) to 3.3 log(10) IU/ml (10 mg QD in genotype 1b and 30 mg QD). E(max) modeling indicated GS-5885 30 mg was associated with>95% of maximal antiviral response to HCV genotype 1a. HCV RNA reductions were generally more sustained among patients with genotype 1b vs. 1a. Three of 60 patients had a reduced response and harbored NS5A-resistant virus at baseline. NS5A sequencing identified residues 30 and 31 in genotype 1a, and 93 in genotype 1b as the predominant sites of mutation following GS-5885 dosing. Plasma pharmacokinetics was consistent with QD dosing For the detailed information of Ledipasvir, the solubility of Ledipasvir in water, the solubility of Ledipasvir in DMSO, the solubility of Ledipasvir in PBS buffer, the animal experiment (test) of  Ledipasvir, the cell expriment (test) of Ledipasvir, the in vivo, in vitro and clinical trial test of Ledipasvir, the EC50, IC50,and affinity,of Ledipasvir, Please contact DC Chemicals.