SKF-86002 supplier|SKF86002|DC Chemicals

SKF-86002 supplier|SKF86002|DC Chemicals
DC Chemicals provides SKF-86002, other names: SKF 86002，SKF86002, cas: 72873-74-6. In stock.

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SKF-86002 is a potent inhibitor of p38 MAP kinase wit IC50 of 0.5-1 uM; inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM).

SKF-86002, other names: SKF 86002，SKF86002, cas: 72873-74-6, Molecule formular: C16H12FN3S, Molecule Weight: 297.35, Chemical name: 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole

SKF-86002 inhibited prostaglandin H2 (PGH2) synthase activity (IC50 120 microM) as well as prostanoid production by rat basophilic leukemia (RBL-1) cells (IC50 70 microM) and its sonicate (IC50 100 microM) and human monocytes (IC50 1 microM). In addition, SK&F 86002 inhibited the generation of dihydroxyeicosatetraenoic acid (diHETE) and 5-hydroxyeicosatetraenoic acid (5-HETE) by a high speed supernatant fraction of RBL-1 cells (IC50 10 microM) [1]. differentiation of HL-60 cells toward the neutrophil phenotype resulted in a loss in c-Jun NH2-terminal kinase activation with concomitant acquisition of formylmethionylleucylphenylalanine-stimulatable and stress-inducible p38 MAPK activity as well as apoptosis blockade by SKF-86002 [2]. SKF-86002 blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP For the detailed information of SKF-86002, the solubility of SKF-86002 in water, the solubility of SKF-86002 in DMSO, the solubility of SKF-86002 in PBS buffer, the animal experiment (test) of  SKF-86002, the cell expriment (test) of SKF-86002, the in vivo, in vitro and clinical trial test of SKF-86002, the EC50, IC50,and affinity,of SKF-86002, Please contact DC Chemicals.