UNC2025 supplier| UNC-2025|DC Chemicals
DC Chemicals provides UNC2025, other names: UNC-2025; UNC2025; UNC 2025., cas: 1429881-91-3. In stock.
Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643261；
UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.
UNC2025, other names: UNC-2025; UNC2025; UNC 2025., cas: 1429881-91-3, Molecule formular: C28H40N6O, Molecule Weight: 476.66, Chemical name: (1r,4r)-4-(2-(butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol
UNC2025 was capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome pro?ling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that 11 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined. For the detailed information of UNC2025, the solubility of UNC2025 in water, the solubility of UNC2025 in DMSO, the solubility of UNC2025 in PBS buffer, the animal experiment (test) of UNC2025, the cell expriment (test) of UNC2025, the in vivo, in vitro and clinical trial test of UNC2025, the EC50, IC50,and affinity,of UNC2025, Please contact DC Chemicals.
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