MS436 |cas 1395084-25-9 |From Supplier DC Chemicalsicals

MS436 |cas 1395084-25-9 |From Supplier DC Chemicalsicals 

DC Chemicals supplies: MS436,cas: 1395084-25-9,Catalog: DC7620,In stock

Contact: website: www.dcchemicals.com,

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Product name: MS436, Synonyms: MS-436; MS 436, cas: 1395084-25-9, MW: 383.42, Molecule Formula: C18H17N5O3S

MS436, cas: 1395084-25-9, Purity:>98%,Supplied by DC ChemicalsMS436 is a diazobenzene-based small-molecule inhibitor for the BRD4 bromodomains with a Ki value of 30-50 nM.

MS436 is a diazobenzene-based small-molecule inhibitor  For the BRD4 bromodomains with a Ki value of 30-50 nM.

IC50 Value: 30-50 nM (Ki) [1]

Target: BRD4 bromodomain

MS436 exhibits low nanomolar affinity (estimated Ki of 30-50 nM), with preference  For the first bromodomain over the second. MS436 effectively inhibits BRD4 activity in NF-κB-directed production of nitric oxide and proinflammatory cytokine interleukin-6 in murine macrophages. MS436 represents a new class of bromodomain inhibitors and will facilitate further investigation of the biological functions of the two bromodomains of BRD4 in gene expression [1] .For the detailed information of MS436, the solubility of MS436 in water, the solubility of MS436 in DMSO, the solubility of MS436 in PBS buffer, the animal experiment (test) of  MS436, the cell expriment (test) of MS436, the in vivo, in vitro and clinical trial test of MS436, the EC50, IC50,and Affinity of MS436, Please contact DC Chemicals.