PF-06687859(RG-3039) supplier|DC Chemicals
DC Chemicals provides PF-06687859/RG-3039 , other names: PF06687859，RG-3039 ，PF 06687859，RG 3039 , cas: 1005504-62-0 (RG3039 free base); 1466525-84-7 (RG3039·2HCl). In stock.
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RG3039 is a small molecule inhibitor of decapping enzyme scavenger (DCPS).
PF-06687859/RG-3039 , other names: PF06687859，RG-3039 ，PF 06687859，RG 3039 , cas: 1005504-62-0 (RG3039 free base); 1466525-84-7 (RG3039·2HCl), Molecule formular: C21H23Cl2N5O, Molecule Weight: 431.13, Chemical name: 5-((1-(2,6-dichlorobenzyl)piperidin-4-yl)methoxy)quinazoline-2,4-diamine
RG3039, also known as PF-06687859, is a potent DcpS inhibitor. DcpS is a therapeutic target for spinal muscular atrophy. Spinal muscular atrophy (SMA) is caused by deletion or mutation of both copies of the SMN1 gene which produces an essential protein known as SMN. RG3039 improves motor function in SMA mice. RG3039 also showed activity to improve survival, function and motor unit pathologies in two SMA mouse models. (Last updated: 2/5/2015) For the detailed information of PF-06687859/RG-3039 , the solubility of PF-06687859/RG-3039 in water, the solubility of PF-06687859/RG-3039 in DMSO, the solubility of PF-06687859/RG-3039 in PBS buffer, the animal experiment (test) of PF-06687859/RG-3039 , the cell expriment (test) of PF-06687859/RG-3039 , the in vivo, in vitro and clinical trial test of PF-06687859/RG-3039 , the EC50, IC50,and affinity,of PF-06687859/RG-3039 , Please contact DC Chemicals.
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