DC Chemicals supplies: PA-824,cas: 187235-37-6,Catalog: DC7625,In stock.
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Product name: PA-824, Synonyms: PA-824,PA824,PA 824, cas: 187235-37-6, MW: 359.26, Molecule Formula: C14H12F3N3O5
PA-824, cas: 187235-37-6, From DC Chemicals. PA-824 is an anti-tuberculosis drug for tuberculosis with MIC less than 2.8 μM.Phase 2.
In vitro, PA-824 exhibits the high activity against multidrug-resistant clinical isolates from Asia (India and South Korea) and from throughout the United States (MIC < 1 μg/ml) and is equally active against the drug-sensitive and multidrug-resistant isolates of M. tuberculosis (MICs range, 0.039 to 0.531 μg/ml). [1] A recent study shows that single-nucleotide polymorphisms of PA-824 resistance genes (fgd1 [Rv0407] and ddn [Rv3547]) don't significantly affect the PA-824 MICs (≤ 0.25 μg/ml). [2] In the rapid tuberculosis mouse model, PA-824 shows significant anti-microbial activity in a dose-dependent manner: at 50 mg/kg, PA-824 in MC produces a more than 1-log reduction of the CFU in the lungs; at 100 mg/kg it produces about a 2-log reduction, and at 300 mg/kg it produces a 3-log reduction. Furthermore, long-term treatment of PA-824 at 100 mg/kg in cyclodextrin/lecithin also leads to the reduction of the bacterial load below 500 CFU in the lungs and spleen. [1] PA-824 exhibits time-dependent anti-microbial activity in a murine model of tuberculosis with a maximal observed bactericidal effect of 0.1 log CFU/day over 24 days. [3]For the detailed information of PA-824, the solubility of PA-824 in water, the solubility of PA-824 in DMSO, the solubility of PA-824 in PBS buffer, the animal experiment (test) of PA-824, the cell expriment (test) of PA-824, the in vivo, in vitro and clinical trial test of PA-824, the EC50, IC50,and Affinity of PA-824, Please contact DC Chemicals.
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