YK-4-279 supplier|YK-4279|DC Chemicals
DC Chemicals provides YK-4-279, other names: YK-4279, cas: 1037184-44-3. In stock.
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YK 4-279 is an inhibitor of RNA Helicase A (RHA) binding to the oncogenic transciption factor EWS-FLI1.
YK-4-279, other names: YK-4279, cas: 1037184-44-3, Molecule formular: C17H13Cl2NO4, Molecule Weight: 366.2, Chemical name: 4,7-dichloro-1,3-dihydro-3-hydroxy-3-[2-(4-methoxyphenyl)-2-oxoethyl]-2H-indole-2-one
ES-FLI1 is an oncogenic fusion protein found in Ewing’s sarcoma, a family of undifferentiated tumors that occur throughout the body. The binding of RNA helicase A (RHA) to ES-FLI1 promotes its oncogenic function. YK-4-279 is an inhibitor of protein-protein interactions between ES-FLI1 and RHA. At 10 µM, YK-4-279 blocks RHA binding to ES-FLI1 and induces apoptosis of a panel of Ewing’s sarcoma tumor cell lines with IC50 values ranging from 0.5-2 µM.1 At 1.5 mg per dose, YK-4-279 reduces the growth of Ewing’s sarcoma orthotopic xenografts in mice after treatment with the inhibitor for two weeks.1 For the detailed information of YK-4-279, the solubility of YK-4-279 in water, the solubility of YK-4-279 in DMSO, the solubility of YK-4-279 in PBS buffer, the animal experiment (test) of YK-4-279, the cell expriment (test) of YK-4-279, the in vivo, in vitro and clinical trial test of YK-4-279, the EC50, IC50,and affinity,of YK-4-279, Please contact DC Chemicals.
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