DC Chemicals supplies: INH1,cas: 313553-47-8,Catalog: DC7640,In stock.
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Product name: INH1, Synonyms: INH-1, INH 1, cas: 313553-47-8, MW: 308.4, Molecule Formula: C18H16N2OS
INH1, cas: 313553-47-8, From DC Chemicals. INH1 is a cell-permeable Hec1 inhibitor, which specifically disrupts the Hec1/Nek2 interaction.
INH1 reduces the association of Hec1 with kinetochore and decreases global Nek2 protein level in cells. INH1 effectively inhibits the proliferation of human breast cancer lines with GI50 of 10-21 μM. Moreover, INH1 also elicits cell killing activity in part through impairing the Hec1/Nek2 pathway For the spindle checkpoint regulation. INH1 (100 mg/kg i.p.) inhibits breast tumor growth in mice bearing MDA-MB-468 human breast cancer xenograft. For the detailed information of INH1, the solubility of INH1 in water, the solubility of INH1 in DMSO, the solubility of INH1 in PBS buffer, the animal experiment (test) of INH1, the cell expriment (test) of INH1, the in vivo, in vitro and clinical trial test of INH1, the EC50, IC50,and Affinity of INH1, Please contact DC Chemicals.
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