KX1-004|cas 518058-84-9|Price|Buy|Supplier|DC Chemicals

KX1-004|cas 518058-84-9|Price|Buy|Supplier|DC Chemicals

DC Chemicals supplies: KX1-004,cas: 518058-84-9,Catalog: DC7582,In stock.

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Product name: KX1-004, Synonyms: KX1 004, cas: 518058-84-9, MW: 284.29, Molecule Formula: C16H13FN2O2

KX1-004, cas 518058-84-9, Purity>98%. Best price and quality from DC Chemicals. WHI-P154 is a potent JAK3 inhibitor with IC50 of 1.8 μM, no activity against JAK1 or JAK2, also inhibits EGFR, Src, Abl, VEGFR and MAPK, prevents Stat3, but not Stat5 phosphorylation.

KX1-004, KX1-005 and KX1-174 as potential protective drugs  For NIHL. Chinchillas were used as subjects. A 30 microl drop of one of the Src inhibitors was placed on the round window membrane of the anesthetized chinchilla; the vehicle (DMSO and buffered saline) alone was placed on the other ear. After the drug application, the middle ear was sutured and the subjects were exposed to noise. Hearing was measured be Fore and several times after the noise exposure and treatment using evoked responses. At 20 days post-exposure, the animals were anesthetized their cochleae extracted and cochleograms were constructed. All three Src inhibitors provided protection from a 4 h, 4 kHz octave band noise at 106 dB. The most effective drug, KX1-004 was further evaluated by repeating the exposure with different doses, as well as, substituting an impulse noise exposure [1]. LNAC was delivered intraperitoneally at a dose of 325 mg/kg while KX1-004 was administered subcutaneously at a dose of 50 mg/kg. The noise exposure consisted of a 4 kHz octave band of noise at 100 dB SPL  For 6 hours/day  For 4 days. The drugs were administered once each day, 30 minutes prior to the onset of the noise exposure. The animals' hearing was estimated using the evoked response records from surgically-implanted chronic electrodes in the inferior colliculi. Animals treated with LNAC and KX1-004 had from 10 to 20 dB less temporary threshold shift at day 1 and an average 10 dB less permanent threshold shift by day 21 when compared to control saline treated animals [2].For the detailed information of KX1-004, the solubility of KX1-004 in water, the solubility of KX1-004 in DMSO, the solubility of KX1-004 in PBS buffer, the animal experiment (test) of  KX1-004, the cell expriment (test) of KX1-004, the in vivo, in vitro and clinical trial test of KX1-004, the EC50, IC50,and Affinity of KX1-004, Please contact DC Chemicals.