XMD17-109 |cas 1435488-37-1 |From Supplier DC Chemicalsicals

XMD17-109 |cas 1435488-37-1 |From Supplier DC Chemicalsicals 

DC Chemicals supplies: XMD17-109,cas: 1435488-37-1,Catalog: DC7624,In stock.

Contact: website:www.dcchemicals.com,

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Product name: XMD17-109, Synonyms: XMD17 109,XMD17109, cas: 1435488-37-1, MW: 638.8, Molecule Formula: C36H46N8O3

XMD17-109, cas: 1435488-37-1, Purity:>98%,Supplied by DC ChemicalsXMD17-109 is a novel, specific ERK-5 inhibitor with an EC50 4.2 uM in HEK293 cells.

Description:

IC50 Value: 4.2±0.69 uM(EC50, inhibits ERK5-mediated AP1 transcriptional activity in HEK 293 cells) 

XMD17-109 is a novel, specific ERK-5 inhibitor with an EC50 4.2uM in HEK293 cells.

In vitro: The pAP1-luciferase reporter and pRL-CMV-Renilla plasmids were co-transfected with plasmids encoding  For ERK5 and constitutively active MEK5 (MEK5DD) in HEK293 cells. Cells were treated with the indicated amounts of compound 26 (XMD17-109)  For 24 h, and lysates were subjected to the dual-luciferase assay. Compound 26 completely inhibited the ERK5-mediated AP1 transcriptional activity at 30 μM and had an EC50 of 4.2 ± 0.7 μM. By contrast 24 had an EC50 of >30 μM.

in vivo: N/A

Clinical trial: N/AFor the detailed information of XMD17-109, the solubility of XMD17-109 in water, the solubility of XMD17-109 in DMSO, the solubility of XMD17-109 in PBS buffer, the animal experiment (test) of  XMD17-109, the cell expriment (test) of XMD17-109, the in vivo, in vitro and clinical trial test of XMD17-109, the EC50, IC50,and Affinity of XMD17-109, Please contact DC Chemicals.