DC Chemicals supplies: Lesinurad (RDEA594）,cas: 878672-00-5,Catalog: DC7631,In stock.
Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643258；
Product name: Lesinurad (RDEA594）, Synonyms: RDEA 594; RDEA-594; RDEA594, cas: 878672-00-5, MW: 404.28, Molecule Formula: C17H14BrN3O2S
Lesinurad (RDEA594）, cas: 878672-00-5, From DC Chemicals. Lesinurad(RDEA594), once-daily inhibitor of URAT1, is a transporter in the kidney that regulates uric acid excretion from the body.
Lesinurad(RDEA594), once-daily inhibitor of URAT1, is a transporter in the kidney that regulates uric acid excretion from the body.
IC50 Value:
Target: URAT1
in vitro:
in vivo: In healthy subjects, the combination of 40 mg FBX with RDEA-594 reduced sUA by approximately 70% at the 200 mg and 400 mg RDEA-594 dose levels, respectively. In gout patients, FBX 40 mg and 80 mg alone reduced sUA by 35% and 47%, respectively. FBX 40 mg + RDEA-594 reduced sUA by 56% and 61% when combined with RDEA-594 400 mg or 600 mg. respectively, resulting in response rates of 100% For sUA <6 and <5 mg/dl and 64% <4 mg/dl. FBX 80 mg + RDEA-594 reduced sUA by 65% and 73% when combined with RDEA-594 400 mg or 600 mg respectively [1]. Following single dosing of RDEA594, exposure of RDEA594 was significantly higher than those obtained from RDEA 806 dosing, >5X at 20 mg/kg in rats and >10X at 30 mg/kg in monkeys [2].
Clinical trial: Lesinurad and Febuxostat Combination Extension Study in Gout .Phase3For the detailed information of Lesinurad (RDEA594）, the solubility of Lesinurad (RDEA594） in water, the solubility of Lesinurad (RDEA594） in DMSO, the solubility of Lesinurad (RDEA594） in PBS buffer, the animal experiment (test) of Lesinurad (RDEA594）, the cell expriment (test) of Lesinurad (RDEA594）, the in vivo, in vitro and clinical trial test of Lesinurad (RDEA594）, the EC50, IC50,and Affinity of Lesinurad (RDEA594）, Please contact DC Chemicals.
没有评论:
发表评论