TBPB supplier||DC Chemicals

TBPB supplier||DC Chemicals
DC Chemicals provides TBPB, other names: , cas: 634616-95-8. In stock.

Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643262；

TBPB is an allosteric M1 mAChR agonist(EC50=289 nM) that regulates amyloid processing and produces antipsychotic-like activity in rats.

TBPB, other names: , cas: 634616-95-8, Molecule formular: C25H32N4O, Molecule Weight: 404.55, Chemical name:

TBPB activates M(1) through an allosteric site rather than the orthosteric acetylcholine binding site, which is likely critical for its unprecedented selectivity. Whole-cell patch-clamp recordings demonstrated that activation of M(1) by TBPB potentiates NMDA receptor currents in hippocampal pyramidal cells but does not alter excitatory or inhibitory synaptic transmission, responses thought to be mediated by M(2) and M(4)。TBPB was efficacious in models predictive of antipsychotic-like activity in rats at doses that did not produce catalepsy or peripheral adverse effects of other mAChR agonists For the detailed information of TBPB, the solubility of TBPB in water, the solubility of TBPB in DMSO, the solubility of TBPB in PBS buffer, the animal experiment (test) of  TBPB, the cell expriment (test) of TBPB, the in vivo, in vitro and clinical trial test of TBPB, the EC50, IC50,and affinity,of TBPB, Please contact DC Chemicals.