DC Chemicals supplies: MK0752,cas: 471905-41-6,Catalog: DC7666,In stock.
Contact: website: www.dcchemicals.com,
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Product name: MK0752, Synonyms: MK-0752,MK-0752, cas: 471905-41-6, MW: 442.9, Molecule Formula: C21H21ClF2O4S
MK0752, cas: 471905-41-6, MK-0752,MK-0752, Purity:>98%. Best Price and high quality from DC Chemicals. MK-0752 is a moderately potent γ-secretase inhibitor, which reduces Aβ40 production with IC50 of 5 nM. Phase 1/2.
MK-0752 is identified as a moderately potent γ-secretase inhibitor, which reduces Aβ40 in a dose-dependent manner with an IC50 of 5 nM in human SH-SY5Y cells. In vitro, MK-0752 blocks Notch-intracellular domain (ICD) cleavage and its subsequent nuclear translocation. MK-0752 (240 mg/kg) reduces the generation of newly produced Aβ with 90% decrease of AUV in the brain of rhesus monkeys. In addition, MK-0752 treatment increases levels of Aβ 1-14, Aβ 1-15, and Aβ 1-16, while decreases levels of Aβ 1-17. In guinea-pigs, oral administration of MK-0752 (10 mg/kg -30 mg/kg) results in the dose-dependent reduction of Aβ40 in plasma, brain and cerebrospinal fluid (CSF) with IC50 of 440 nM in brain.For the detailed information of MK0752, the solubility of MK0752 in water, the solubility of MK0752 in DMSO, the solubility of MK0752 in PBS buffer, the animal experiment (test) of MK0752, the cell expriment (test) of MK0752, the in vivo, in vitro and clinical trial test of MK0752, the EC50, IC50,and Affinity of MK0752, Please contact DC Chemicals.
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