GW4869|cas 6823-69-4|buy|Price|from DC Chemicalsicals

GW4869|cas 6823-69-4|buy|Price|from DC Chemicalsicals

DC Chemicals supplies: GW4869,cas: 6823-69-4,Catalog: DC7662,In stock.

Contact: website: www.dcchemicals.com,

sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,

Tel: +86-21-58447131;Fax:+86-21-61643258；

Product name: GW4869, Synonyms: GW-4869 ,GW 4869 , cas: 6823-69-4, MW:  595.51948, Molecule Formula: C30H32Cl2N6O3

GW4869, cas: 6823-69-4, From DC Chemicals. GW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase). 

GW4869 is a cell permeable, selective inhibitor of N-SMase (neutral sphingomyelinase). GW4869 functions as an inhibitor, via a non-competitve manner. N-SMases are important in the metabolism of sphingomyelin producing ceramide and phosphocholine, which are important in cell signaling and regulation. Studies indicate that GW4869 can inhibit the activation of N-SMase by TNF-α in MC7 cells. As a result of this inhibition cell death and growth suppression are inhibited. Although GW4869 does not effect polymorphonuclear neutrophil (PMN) motility, it is useful with  Formylmethionylleucylphenylanaline (FMLP), since it inhibits PMN aggregation towards the chemotaxin.For the detailed information of GW4869, the solubility of GW4869 in water, the solubility of GW4869 in DMSO, the solubility of GW4869 in PBS buffer, the animal experiment (test) of  GW4869, the cell expriment (test) of GW4869, the in vivo, in vitro and clinical trial test of GW4869, the EC50, IC50,and Affinity of GW4869, Please contact DC Chemicals.