DC Chemicals supplies: Sivelestat (LY54434),cas: 127373-66-4,Catalog: DC7644,In stock.
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Product name: Sivelestat (LY54434), Synonyms: EI546; LY544349; ONO5046, cas: 127373-66-4, MW: 434.46, Molecule Formula: C20H22N2O7S
Sivelestat (LY54434), cas: 127373-66-4, From DC Chemicals. Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.
Sivelestat(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse.
IC50 value: 44 nM [1]
Target: neutrophil elastase
ONO-5046 did not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 microM. In in vivo studies, ONO-5046 suppressed lung hemorrhage in hamster (ID50 = 82 micrograms/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase [1]. Sivelestat sodium hydrate is an anti-neutrophil elastase inhibitor and may be one of the treatment options For acute respiratory failure due to pneumocystis pneumonia in AIDS patients [2].For the detailed information of Sivelestat (LY54434), the solubility of Sivelestat (LY54434) in water, the solubility of Sivelestat (LY54434) in DMSO, the solubility of Sivelestat (LY54434) in PBS buffer, the animal experiment (test) of Sivelestat (LY54434), the cell expriment (test) of Sivelestat (LY54434), the in vivo, in vitro and clinical trial test of Sivelestat (LY54434), the EC50, IC50,and Affinity of Sivelestat (LY54434), Please contact DC Chemicals.
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