DC Chemicals supplies: Palifosfamide,cas: 31645-39-3,Catalog: DC7659,In stock.
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Product name: Palifosfamide, Synonyms: Isophosphoramide mustard; IPM; ZIO-201, cas: 31645-39-3, MW: 221.02, Molecule Formula: C4H11Cl2N2O2P
Palifosfamide, cas: 31645-39-3, From DC Chemicals. Palifosfamide (ZIO-201) is the functional active metabolite of ifosfamide (IFOS), a bi-functional DNA alkylator being investigated as a potential therapy for the treatment of soft tissue sarcoma (STS).
Palifosfamide (ZIO-201) is the functional active metabolite of ifosfamide (IFOS), a bi-functional DNA alkylator being investigated as a potential therapy For the treatment of soft tissue sarcoma (STS).
IC50 Value: 0.5-1.5mg/ml [1]
Target: DNA alkylator
in vitro: Palifosfamide lysine was cytotoxic against all the cell lines tested with the IC(50) ranging from 0.5 to 1.5 microg/ml except For OS222, which had an IC(50) of 7 microg/ml [1].
in vivo: Dose response, route and schedule of administration, and interaction with docetaxel or doxorubicin were investigated in NCr-nu/nu mice bearing established orthotopic mammary MX-1 tumor xenografts. Oral activity was investigated in P388-1 leukemia in CD2F1 mice. Oral and intraperitoneal bioavailabilities were compared in Sprague-Dawley rats. Stabilized palifosfamide administered by optimized regimens suppressed MX-1 tumor growth (P<0.05) by greater than 80% with 17% complete antitumor responses and up to three-fold increase in time to three tumor doublings over controls. Median survival in the P388-1 (P<0.001) model was increased by 9 days over controls [2]. The IV MTD of palifosfamide lysine in mice was 100 mg/kg per day For three consecutive days. Tumor growth inhibition was seen in both OS31 and OS33 xenografts and the RMS xenograft resulting in a significant difference in event-free survival between the control and the treated groups [1].
Clinical trial: PICASSO: A Study of Palifosfamide Tris Plus Doxorubicin Versus Doxorubicin in Unresectable or Metastatic Soft-Tissue Sarcoma . Phase2For the detailed information of Palifosfamide, the solubility of Palifosfamide in water, the solubility of Palifosfamide in DMSO, the solubility of Palifosfamide in PBS buffer, the animal experiment (test) of Palifosfamide, the cell expriment (test) of Palifosfamide, the in vivo, in vitro and clinical trial test of Palifosfamide, the EC50, IC50,and Affinity of Palifosfamide, Please contact DC Chemicals.
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