DC Chemicals supplies: PNU159682,cas: 202350-68-3,Catalog: DC7648,In stock.
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Product name: PNU159682, Synonyms: PNU159682; PNU 159682, cas: 202350-68-3, MW: 641.62, Molecule Formula: C32H35NO13
PNU159682, cas: 202350-68-3, From DC Chemicals. PNU-159682 is a major bioactive metabolite of Nemorubicin in human liver microsomes; > 3,000-fold cytotoxic than its parent compound(MMDX and doxorubicin).
PNU-159682 is a major bioactive metabolite of Nemorubicin in human liver microsomes; > 3,000-fold cytotoxic than its parent compound(MMDX and doxorubicin).
IC50 value: 0.1-0.5 nM (HT-29; DU145; Jurkat cell lines, etc)
Target: Topoisomerase I inhibitor
in vitro: The cytotoxicity of PNU-159682 were in the subnanomolar range (0.07-0.58 nmol/L) and noticeably lower than that recorded For both MMDX and doxorubicin; PNU-159682 was 2,360- to 790-fold and 6,420- to 2,100-fold more potent than MMDX and doxorubicin, respectively.
in vivo: An evaluation of the in vivo antitumor activity of PNU-159682, in comparison with that of MMDX, was then conducted in mice bearing disseminated murine L1210 leukemia. Preliminary toxicity dose-finding studies showed that 15 Ag/kg i.v. was the single-dose maximum tolerated dose of PNU-159682 . Several patents reported that PNU-159682 can be used as cytotoxin in ADCs design.For the detailed information of PNU159682, the solubility of PNU159682 in water, the solubility of PNU159682 in DMSO, the solubility of PNU159682 in PBS buffer, the animal experiment (test) of PNU159682, the cell expriment (test) of PNU159682, the in vivo, in vitro and clinical trial test of PNU159682, the EC50, IC50,and Affinity of PNU159682, Please contact DC Chemicals.
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