DC Chemicals supplies: UNBS5162,cas: 956590-23-1,Catalog: DC7708,In stock.
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Product name: UNBS5162, Synonyms: UNBS 5162; UNBS-5162, cas: 956590-23-1, MW: 326.35, Molecule Formula: C17H18N4O3
UNBS5162, cas: 956590-23-1, purity>98, from DC Chemicals. UNBS5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers; the mean antiproliferative activity IC50 value is 17.9 uM for 9 cancer cell lines; hydrolysis product of UNBS3157.
UNBS5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers; the mean antiproliferative activity IC50 value is 17.9 uM for 9 cancer cell lines; hydrolysis product of UNBS3157.
IC50 value: 4.7-46.5 uMcancer cell line) [1]
Target: CXCL regulator
in vitro: The mean antiproliferative activity IC50 values determined against nine human cancer cell lines investigated (using the MTT colorimetric assay) were 19.8 and 17.9 μM for UNBS3157 and UNBS5162, respectively [1].
in vivo: In the PC-3 model, UNBS3157 displayed appreciable activity against PC-3 prostate carcinoma when administered orally at 160 mg/kg (%T/C: 151%, P = .03) but not at the lower dose of 40 mg/kg (%T/C: 100%). Repeat i.v. administration of the compound at 10 mg/kg (three times a week for 6 consecutive weeks) contributed therapeutic benefits that were similar to repeat i.v. administration (once a week for 6 consecutive weeks) of 20-mg/kg taxol in the PC-3 orthotopic model [1]. UNBS5162 was administered in a 3 + 3 dose escalation scheme by intravenous infusion over 1 h weekly for 3 weeks of a 4-week cycle. Safety, serial serum PK and tolerability were captured throughout the study. Response Evaluation Criteria in Solid Tumors was utilized every 2 cycles to assess for anti-tumor response [2]. For the detailed information about the solubility of UNBS5162 in water, the solubility of UNBS5162 in DMSO, the solubility of UNBS5162 in PBS buffer, the animal experiment of UNBS5162 ,the in vivo and in vitro test of UNBS5162 ,the cell experiment of UNBS5162 ,the IC50 and EC50 of UNBS5162 please contact DC Chemicals.
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