DC Chemicals supplies: ATN-161,cas: 262438-43-7,Catalog: DC7709,In stock.
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Product name: ATN-161, Synonyms: ATN161; ATN 161, cas: 262438-43-7, MW: 597.64, Molecule Formula: C23H35N9O8S
ATN-161, cas: 262438-43-7, purity>98, from DC Chemicals. ATN-161 (Ac-PHSCN-NH2) is a five -amino-acid peptide derived from the synergy region of fibronectin; a beta integrin antagonist with antitumor activity.
ATN-161 (Ac-PHSCN-NH2) is a five -amino-acid peptide derived from the synergy region of fibronectin; a beta integrin antagonist with antitumor activity.
IC50 value:
Target: Integrin antagonist
in vitro: ATN-161 inhibited VEGF-induced migration and capillary tube formation in hCECs, but did not inhibit proliferation [2].
in vivo: Murine colon cancer cells (CT26) were injected into spleens of BALB/c mice to produce liver metastases. Four days thereafter, mice were given either ATN-161 (100 mg/kg, every 3rd day) or saline by intraperitoneal injection, with or without combination of continuous-infusion 5-FU (100 mg/kg/2 weeks), which was started on day 7. On day 20 after tumor cell inoculation, mice were killed and liver weights and number of liver metastases were determined [1]. ATN-161 after laser photocoagulation inhibited CNV leakage and neovascularization to an extent similar to AF564. Furthermore, SD-OCT and histologic examinations indicated that ATN-161 significantly decreased the size of laser-induced lesions [2]. Treatment with ATN-161 significantly blunts atherosclerotic plaque development in apolipoprotein E-deficient mice, characterized by reduced vascular cell adhesion molecule-1 expression and macrophage accumulation without affecting fibrous cap size. For the detailed information about the solubility of ATN-161 in water, the solubility of ATN-161 in DMSO, the solubility of ATN-161 in PBS buffer, the animal experiment of ATN-161 ,the in vivo and in vitro test of ATN-161 ,the cell experiment of ATN-161 ,the IC50 and EC50 of ATN-161 please contact DC Chemicals.
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