DC Chemicals supplies: AHU-377 ( LCZ696),cas: 149709-62-6,Catalog: DC7707,In stock.
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Product name: AHU-377 ( LCZ696), Synonyms: AHU377, AHU 377, cas: 149709-62-6, MW: 411.49, Molecule Formula: C24H29NO5
AHU-377 ( LCZ696), cas: 149709-62-6, purity>98, from DC Chemicals. AHU-377 is a potent neprilysin inhibitor with IC50 of 5.0 nM; a component of LCZ696.
AHU-377 is a potent neprilysin inhibitor with IC50 of 5.0 nM; a component of LCZ696.
IC50 Value: 5.0 nM
Target: neprilysin
in vitro:
in vivo: LCZ696 is a novel single molecule comprising molecular moieties of valsartan and NEP inhibitor prodrug AHU377 (1:1 ratio). Oral administration of LCZ696 caused dose-dependent increases in atrial natriuretic peptide immunoreactivity (due to NEP inhibition) in Sprague-Dawley rats and provided sustained, dose-dependent blood pressure reductions in hypertensive double-transgenic rats. In healthy participants, a randomized, double-blind, placebo-controlled study (n = 80) of single-dose (200-1200 mg) and multiple-dose (50-900 mg once daily for 14 days) oral administration of LCZ696 showed that peak plasma concentrations were reached rapidly for valsartan (1.6-4.9 hours), AHU377 (0.5-1.1 hours), and its active moiety, LBQ657 (1.8-3.5 hours). [1]. LCZ696 is superior to valsartan alone in reducing blood pressure. Preliminary results from a Phase II trial showed that LCZ696 reduced NT-proBNP to a greater extent than valsartan alone, and in addition LCZ696 had beneficial effects on symptoms [2]. For the detailed information about the solubility of AHU-377 ( LCZ696) in water, the solubility of AHU-377 ( LCZ696) in DMSO, the solubility of AHU-377 ( LCZ696) in PBS buffer, the animal experiment of AHU-377 ( LCZ696) ,the in vivo and in vitro test of AHU-377 ( LCZ696) ,the cell experiment of AHU-377 ( LCZ696) ,the IC50 and EC50 of AHU-377 ( LCZ696) please contact DC Chemicals.
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