MMAD|buy from supplier D&C Chemicals

MMAD|buy from supplier D&C Chemicals

DC Chemicals supplies: MMAD,cas: 203849-91-6,Catalog: DC7690,In stock.

Contact: website: www.dcchemicals.com,

sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,

Tel: +86-21-58447131;Fax:+86-21-61643258；

Product name: MMAD, Synonyms: Demethyldolastatin 10; Monomethylauristatin D; Monomethyl Dolastatin 10, cas: 203849-91-6, MW: 771.06, Molecule Formula: C41H66N6O6S

MMAD, purity: >98%, Best price from D&C Chemicals. Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload in antibody drug conjugate.

Monomethyl auristatin D (MMAD), a potent tubulin inhibitor, is a toxin payload and antibody drug conjugate.

For comparison purposes, the ADC A1 -mc-MMAD and/or A1 -vc-MMAD were used. The linker payload, mc-MMAD (6-maleimidocaproyl-monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule. The linker payload mc- Val-Cit-PABA-MMAD or vc-MMAD (maleimidocapronic -valine-citruline-p- aminobenzyloxycarbonyl- monomethylauristatin-D) was conjugated to the A1 anti-5T4 monoclonal antibody through a cysteine residue at a ratio of approximately 4 drug moieties per antibody molecule (Antibody-drug conjugates Patent: WO 2013068874 A1).

 For the detailed information about the solubility of MMAD in water, the solubility of MMAD in DMSO, the solubility of MMAD in PBS buffer, the animal experiment of MMAD,the in vivo and in vitro test of MMAD,the cell experiment of MMAD,the IC50 and EC50 of MMAD please contact DC Chemicals.