DC Chemicals supplies: HTH-01-015,cas: 1613724-42-7,Catalog: DC7705,In stock.
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Product name: HTH-01-015, Synonyms: , cas: 1613724-42-7, MW: 468.55, Molecule Formula: C26H28N8O
HTH-01-015, cas: 1613724-42-7, purity>98, from DC Chemicals. HTH-01-015 is a selective inhibitor of NUAK1 kinase with an IC50 value of 100 nM.
HTH-01-015 is a highly specific inhibitor of NUAK1 with IC50 value of 100 nM 1.
HTH-01-015 showed extreme selectivity. It only inhibited the NUAK1 (NUAK family SNF1-like kinase-1) isoform of NUAK kinases and showed no significant inhibition of 139 other tested kinases. HTH-01-015 inhibited the phosphorylation of the NUAK1 substrate, MYPT1. The phosphorylated site was identified as Ser445. In HEK cells overexpressing drug-resistant NUAK1, HTH-01-015 displayed no more inhibition effect on MYPT1. In MEF cells, HTH-01-015 markedly reduced cell migration in the wound-healing assay. Besides that, HTH-01-015 impaired the proliferation at concentration of 10 μM both in U2OS cells and in MEF cells. Moreover, 10 μM HTH-01-015 also significantly inhibited the invasiveness of U2OS cells in a 3D matrigel transwell invasion assay 1. For the detailed information about the solubility of HTH-01-015 in water, the solubility of HTH-01-015 in DMSO, the solubility of HTH-01-015 in PBS buffer, the animal experiment of HTH-01-015 ,the in vivo and in vitro test of HTH-01-015 ,the cell experiment of HTH-01-015 ,the IC50 and EC50 of HTH-01-015 please contact DC Chemicals.
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