BAF312|BAF-312|buy from supplier D&C Chemicals

BAF312|BAF-312|buy from supplier D&C Chemicals

DC Chemicals supplies: BAF312,cas: N/A,Catalog: DC7694,In stock.

Contact: website: www.dcchemicals.com,

sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,

Tel: +86-21-58447131;Fax:+86-21-61643258；

Product name: BAF312, Synonyms: Siponimod; CHEMBL2336071; Siponimod [INN]; BAF-312, BAF 312, cas: N/A, MW: 516.59501, Molecule Formula: C29H35F3N2O3 

BAF312, purity: >98%, Best price from D&C Chemicals. BAF312 is a potent and selective agonist of S1P with EC50 value of 0.39nM for S1P1 receptors and 0.98nM for S1P5 receptors, respectively

BAF312 is a potent and selective agonist of S1P with EC50 value of 0.39nM for S1P1 receptors and 0.98nM for S1P5 receptors, respectively [1].

BAF312 has shown >1000-fold selectivity for S1P1 versus S1P2, S1P3 and S1P4 receptors [1]. In vitro metabolism studies with liver microsomes have shown that the metabolic clearance of BAF312 is high in rat, low to moderate in monkey and human being, and low in dog and mouse. Moreover, BAF312 has been revealed to dose-dependently reduce peripheral lymphocyte counts in Lewis rats [2].For the detailed information about the solubility of BAF312  in water, the solubility of BAF312  in DMSO, the solubility of BAF312  in PBS buffer, the animal experiment of BAF312 ,the in vivo and in vitro test of BAF312 ,the cell experiment of BAF312 ,the IC50 and EC50 of BAF312  please contact DC Chemicals.