YC-1(Lificiguat)|From DC Chemicalsicals

YC-1(Lificiguat)|From DC Chemicalsicals

DC Chemicals supplies: YC-1(Lificiguat),cas: 170632-47-0,Catalog: DC7720,In stock.

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Product name: YC-1(Lificiguat), Synonyms: Lificiguat; YC 1, cas: 170632-47-0, MW: 304.34, Molecule Formula: C19H16N2O2

Purchase YC-1(Lificiguat) with high quality and good price from DC Chemicals.YC-1(Lificiguat) is a soluble guanylyl cyclase(sGC) activator; binds to the heme-containing domain of the β subunit with Kd value of 0.6-1.1 μM in the presence of CO.

YC-1(Lificiguat) is a soluble guanylyl cyclase(sGC) activator; binds to the heme-containing domain of the β subunit with Kd value of 0.6-1.1 μM in the presence of CO.

in vitro: YC-1 and related compounds stimulate sGC both independently and synergistically with NO and CO binding. YC-1 binds near or directly to the heme-containing domain of the β subunit. In the absence of CO, YC-1 binds with a Kd of 9-21 μM, depending on the construct. In the presence of CO, these values decrease to 0.6-1.1 μM. Pfizer compound 25 bound ～10-fold weaker than YC-1 in the absence of CO, whereas compound BAY 41-2272 bound particularly tightly in the presence of CO (Kd = 30-90 nM) .In vitro, combination of sorafenib and YC-1 synergistically inhibited proliferation and colony formation of HepG2, BEL-7402 and HCCLM3 cells. The combination also induced S cell cycle arrest and apoptosis, as observed by activated PARP and caspase 8. Sorafenib and YC-1 respectively suppressed the expression of phosphorylated STAT3 (p-STAT3) (Y705) in a dose- and time-dependent manner .

in vivo: YC-1 reduced the viability of breast cancer cells and tumour growth in MDA-MB-468 xenografts. In breast cancer cells, YC-1 down-regulated EZH2 expression in a concentration- and time-dependent manner . Rats received YC-1 (1 mg/kg/day) for 2 weeks long-term. YC-1 treatment reversed the reduction of the "time spent in the escape platform's quadrant" of 24-month-old rats.For the detailed information about the solubility of YC-1(Lificiguat)  in water, the solubility of YC-1(Lificiguat)  in DMSO, the solubility of YC-1(Lificiguat)  in PBS buffer, the animal experiment of YC-1(Lificiguat) ,the in vivo and in vitro test of YC-1(Lificiguat) ,the cell experiment of YC-1(Lificiguat) ,the IC50 and EC50 of YC-1(Lificiguat)  please contact DC Chemicals.