DC Chemicals supplies: XEN445,cas: 1515856-92-4,Catalog: DC7715,In stock.
Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643258；
Product name: XEN445, Synonyms: XEN 445; XEN-445, cas: 1515856-92-4, MW: 366.33, Molecule Formula: C18H17F3N2O3
XEN445, cas: 1515856-92-4, purity>98, from DC Chemicals. XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.
XEN445 is a potent and selective EL inhibitor(IC50=0.237 uM), that showed good ADME and PK properties, and demonstrated in vivo efficacy in raising plasma HDLc concentrations in mice.
IC50 value: 0.237 uM [1]
Target: Endothelial lipase inhibitor
XEN445 can be readily prepared in good yield from commercial available chemicals, which was selected for further evaluation of this series of EL inhibitors. After a 30 min preincubation of EL-expressing HEK cells with XEN445, the IC50 value for XEN445 of 0.25 lM was obtained. This value was very similar to that determined in the cell-free assay. Wild-type mice were orally dosed with XEN445 at 30 mg/kg b.i.d. for 3 days and blood was taken on the morning of day 4, 16 h post ?nal dose. At termination, the average plasma levels of XEN445 was 9.9 lM and the drug caused an 18% and 16% increase in total plasma cholesterol and HDLc, respectively. For the detailed information about the solubility of XEN445 in water, the solubility of XEN445 in DMSO, the solubility of XEN445 in PBS buffer, the animal experiment of XEN445 ,the in vivo and in vitro test of XEN445 ,the cell experiment of XEN445 ,the IC50 and EC50 of XEN445 please contact DC Chemicals.
没有评论:
发表评论