DC Chemicals supplies: UM171 ,cas: 1448724-09-1,Catalog: DC7724,In stock.
Contact: website:www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643258；
Product name: UM171 , Synonyms: UNC-171， UM 171, cas: 1448724-09-1, MW: 453.54, Molecule Formula: C25H27N9
Purchase UM171 with high quality and good price from DC Chemicals.UM171 is a novel and potent agonist Of human hematopoietic stem cell renewal, a new type of bioreactor developed for stem culture
UM171 is 14-25 folds more potent than the starting molecule with an EC50 of 8-15 nM on CD34+ human cord blood (CB). Using the optimal dose of this analog, CD34+, CD34+CD45RA-, and CD34+CD38-CD90+CD45RA-CD49f+ were expanded 115±15, 62±3 and 121±6 fold respectively over the input values after 12 day culture in fed-batch system. The expansion of these phenotypic HSC populations was enhanced, in an additive manner by including SR1. UM171 led to a rapid loss of the CD34+CD45RA- population suggesting that its effect is reversible. UM171 is not a mitogen and cannot compensate for the absence of cytokines added to the media (Flt3L, SCF, and TPO). With the UM171, it will be possible to multiply stem cells in culture and to produce enough of them to treat adults, especially those who are not Caucasian, and who because of the lack of donors have limited access to transplants.For the detailed information about the solubility of UM171 in water, the solubility of UM171 in DMSO, the solubility of UM171 in PBS buffer, the animal experiment of UM171 ,the in vivo and in vitro test of UM171 ,the cell experiment of UM171 ,the IC50 and EC50 of UM171 please contact DC Chemicals.
没有评论:
发表评论