DC Chemicals supplies: Losmapimod,cas: 585543-15-3,Catalog: DC7711,In stock.
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Product name: Losmapimod, Synonyms: GW856553, GSK-AHAB, cas: 585543-15-3, MW: 383.46, Molecule Formula: C22 H26 F N3 O2
Losmapimod, cas: 585543-15-3, purity>98, from DC Chemicals. Losmapimod (GW856553X) is a selective, potent, and orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. Phase 3.
In spontaneously hypertensive stroke-prone rats (SHR-SP), Losmapimod significantly improves survival, endothelial-dependent and -independent vascular relaxation, and indices of renal function, and subsequently attenuates dyslipidemia, hypertension, cardiac remodeling, plasma renin activity (PRA), aldosterone, and interleukin-1beta (IL-1beta). [1] For the detailed information about the solubility of Losmapimod in water, the solubility of Losmapimod in DMSO, the solubility of Losmapimod in PBS buffer, the animal experiment of Losmapimod ,the in vivo and in vitro test of Losmapimod ,the cell experiment of Losmapimod ,the IC50 and EC50 of Losmapimod please contact DC Chemicals.
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