DC Chemicals supplies: Kartogenin (KGN) ,cas: 4727-31-5,Catalog: DC7669,In stock.
Contact: website: www.dcchemicals.com,
sales@dcchemicals.com,order@dcchemicals.com,info@dcchemicals.com,
Tel: +86-21-58447131;Fax:+86-21-61643258；
Product name: Kartogenin (KGN) , Synonyms: KGN, cas: 4727-31-5, MW: 317.34, Molecule Formula: C20H15NO3
Kartogenin (KGN) , cas: 4727-31-5, KGN, Purity:>98%. Best Price and high quality from DC Chemicals. Kartogenin(KGN) is a small molecule stimulator of chondrogenesis; promotes chondrocyte differentiation(EC50=100 nM) and binds to filamin A.
Kartogenin(KGN) is a small molecule stimulator of chondrogenesis; promotes chondrocyte differentiation(EC50=100 nM) and binds to filamin A.
IC50 value: 100 nM(EC50, promotes chondrocyte differentiation)
Target: Chondrogenesis stimulator
Kartogenin is a small molecule kartogenin, which promotes chondrocyte differentiation (median effective concentration = 100 nM), shows chondroprotective effects in vitro, and is efficacious in two OA animal models. Kartogenin binds filamin A, disrupts its interaction with the transcription factor core-binding factor β subunit (CBFβ), and induces chondrogenesis by regulating the CBFβ-RUNX1 transcriptional program. KGN stimulated type-I collagen synthesis of fibroblasts at the mRNA and protein levels in a time-dependent manner, but KGN did not induce expression of α-skeletal muscle actin (α-sma) or matrix metallopeptidase1 (MMP1), MMP9 in vitro . KGN promoted the type-I collagen synthesis of dermal fibroblasts in vitro and in the dermis of mice through activation of the smad4/smad5 pathway.
in vivo: KGN also increased type-I collagen synthesis in the dermis of BALB/C mice.For the detailed information of Kartogenin (KGN) , the solubility of Kartogenin (KGN) in water, the solubility of Kartogenin (KGN) in DMSO, the solubility of Kartogenin (KGN) in PBS buffer, the animal experiment (test) of Kartogenin (KGN) , the cell expriment (test) of Kartogenin (KGN) , the in vivo, in vitro and clinical trial test of Kartogenin (KGN) , the EC50, IC50,and Affinity of Kartogenin (KGN) , Please contact DC Chemicals.
没有评论:
发表评论