DC Chemicals supplies: B-Raf IN 1,cas: 950736-05-7,Catalog: DC7718,In stock.
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Product name: B-Raf IN 1, Synonyms: , cas: 950736-05-7, MW: 515.53, Molecule Formula: C29H24F3N5O
B-Raf IN 1, cas: 950736-05-7, purity>98, from DC Chemicals. B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor with IC50 of 24 nM; equipotent against c-Raf (IC50= 25 nM).
B-Raf IN 1 is a highlt potent and selective B-Raf inhibitor with IC50 of 24 nM; equipotent against c-Raf (IC50= 25 nM).
IC50 value: 24 nM (B-Raf); 25 nM (C-Raf) [1]
Target: B-Raf/C-Raf inhibitor
Compound 10n(B-Raf IN 1) was equipotent against c-Raf (IC50: 0.025 lM) Moderate selectivity was observed for compound 10n versus p38a (IC50: 0.216 lM) and CAMKII (IC50: 0.822 lM), while high selectivity was observed versus CDK2, CDK4, PKCa, IKKb, JNK1, MK2, PKA, Src, MKK6, PLK1, p70S6K, PI3 Ka, and PDK1 (IC50s: >2 lM). For the detailed information about the solubility of B-Raf IN 1 in water, the solubility of B-Raf IN 1 in DMSO, the solubility of B-Raf IN 1 in PBS buffer, the animal experiment of B-Raf IN 1 ,the in vivo and in vitro test of B-Raf IN 1 ,the cell experiment of B-Raf IN 1 ,the IC50 and EC50 of B-Raf IN 1 please contact DC Chemicals.
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