VE-821 |cas 1232410-49-9 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: VE-821 ,cas 1232410-49-9, Cat No. DC3132, In stock

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Product name: VE-821, Synonym:　VE821,VE 821, Cat No. DC3132, Cas: 1232410-49-9, Chemical Name:2-Pyrazinecarboxamide, 3-amino-6-[4-(methylsulfonyl)phenyl]-N-phenyl-, Molecular Formula: C18H16N4O3S, MW: 368.41

VE-821 Cas#1232410-49-9.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! VE-821 is a potent and selective ATP competitive inhibitor of ATR with Ki and IC50 of 13 nM and 26 nM, respectively.

Description of VE-821: VE-821 is the first highly selective and potent ATR inhibitor. VE-821 inhibited radiation- and gemcitabine-induced phosphorylation of Chk1, confirming inhibition of ATR signaling. Consistently, VE-821 significantly enhanced the sensitivity of PSN-1, MiaPaCa-2 and primary PancM pancreatic cancer cells to radiation and gemcitabine under both normoxic and hypoxic conditions. ATR inhibition by VE-821 led to inhibition of radiation-induced G 2/M arrest in cancer cells.

For the detailed information about the solubility of VE-821 in water, the solubility of VE-821 in DMSO, the solubility of VE-821 in PBS buffer, the animal experiment of VE-821,the in vivo and in vitro test of VE-821,the cell experiment of VE-821,the IC50 and EC50 of VE-821please contact DC Chemicals.