R547 |cas 741713-40-6 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: R547 ,cas 741713-40-6, Cat No. DC2068, In stock

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Product name: R547, Synonym:　R-547, R 547, Cat No. DC2068, Cas: 741713-40-6, Chemical Name:(4-amino-2-(1-(methylsulfonyl)piperidin-4-ylamino)pyrimidin-5-yl)(2,3-difluoro-6-methoxyphenyl)methanone, Molecular Formula: C18H21F2N5O4S, MW: 441Description of R547: R547 is orally bioavailable diaminopyrimidine cyclin-dependent kinase inhibitor (CDKI) with potential antineoplastic activity. CDKI R547 selectively binds to and inhibits CDKs, especially CDK1/cyclin B, CDK2/cyclin E, and CDK4/cyclin D1. The inhibition of CDKs results in cell cycle arrest, inhibition of tumor cell proliferation, and induction of apoptosis. Through CDK inhibition, this agent also reduces phosphorylation of the retinoblastoma (Rb) protein, thus preventing activation of transcription factor E2F and so further suppressing tumor cell proliferation. CDKs are ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and are frequently overexpressed in tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

For the detailed information about the solubility of R547 in water, the solubility of R547 in DMSO, the solubility of R547 in PBS buffer, the animal experiment of R547,the in vivo and in vitro test of R547,the cell experiment of R547,the IC50 and EC50 of R547please contact DC Chemicals..45

R547 Cas#741713-40-6.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! R547 is a potent and selective CDK inhibitor with Ki and IC50 of 1-3 nM and 80 nM respectively.