PD-173074 |cas 219580-11-7 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: PD-173074 ,cas 219580-11-7, Cat No. DC2054, In stock

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Product name: PD-173074, Synonym:　PD173074, PD 173074, Cat No. DC2054, Cas: 219580-11-7, Chemical Name:1-tert-butyl-3-(2-(4-(diethylamino)butylamino)-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea, Molecular Formula: C28H41N7O3, MW: 523.67

PD-173074 Cas#219580-11-7.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! PD173074 is a potent FGFR1 inhibitor with IC50 of ~25 nM and also inhibits VEGFR2 with IC50 of 100-200 nM.

Selective FGFR1 and FGFR3 inhibitor (IC50 values are 5, 21.5, ~100, 17600 and 19800 nM for FGFR3, FGFR1, VEGFR2, PDGFR and c-Src respectively, and > 50000 nM for EGFR, InsR, MEK and PKC). Inhibits VEGF- and FGF-induced angiogenesis in the mouse cornea model of angiogenesis. Inhibits proliferation and differentiation of oligodendrocyte progenitors. Suppresses cell proliferation in cell lines expressing mutated FGFR3 protein. Blocks tumor growth in H510 and H69 SCLC xenograft models.

For the detailed information about the solubility of PD-173074 in water, the solubility of PD-173074 in DMSO, the solubility of PD-173074 in PBS buffer, the animal experiment of PD-173074,the in vivo and in vitro test of PD-173074,the cell experiment of PD-173074,the IC50 and EC50 of PD-173074please contact DC Chemicals.