L-165041 |cas 79558-09-1 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: L-165041 ,cas 79558-09-1, Cat No. DC2076, In stock

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Product name: L-165041, Synonym:　L165041, L 165041, Cat No. DC2076, Cas: 79558-09-1, Chemical Name:N/A, Molecular Formula: C22H26O7, MW: 402.44

L-165041 Cas#79558-09-1.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! L-165041 is a potent PPARδ agonist (Ki = 6 nM)

L-165041 is a cell permeable peroxisome proliferator-activated receptor β (PPARβ) agonist which induces adipocyte differentiation in NIH-PPARβ cells. In addition, this ligand reduces lipid accumulation in the liver and decreases total hepatic cholesterol and triglyceride content. Studies suggest that L-165041 affects mRNA expression by reducing the expression of PPARγ, apolipoprotein B, interleukin 1 β (IL-1β), and interleukin-6, while increasing the expression of PPARβ, lipoprotein lipase (LPL), and ATP-binding cassette transporter G1 (ABCG1). Furthermore, upon binding to PPARβ L-165041 suppresses vascular smooth muscle proliferation and migration by inhibiting the cell cycle, specifically blocking G1 to S phase progression and repressing the phosphorylation of retinoblastoma protein (Rb) in rats. Alternate studies suggest that L-165041 suppresses the cytokine-induced expression of VCAM-1 (vascular cell adhesion molecule-1) and increases UCP3 (uncoupling protein 3) gene expression in L6 myotubes.

For the detailed information about the solubility of L-165041 in water, the solubility of L-165041 in DMSO, the solubility of L-165041 in PBS buffer, the animal experiment of L-165041,the in vivo and in vitro test of L-165041,the cell experiment of L-165041,the IC50 and EC50 of L-165041please contact DC Chemicals.