AG 490 |cas 133550-30-8 |DC Chemicals|Supplier|Price|Buy

DC Chemicals Supply: AG 490 ,cas 133550-30-8, Cat No. DC2096, In stock

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Product name: AG490, Synonym:　AG-490, Cat No. DC2096, Cas: 133550-30-8, Chemical Name:(E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide, Molecular Formula: C17H14N2O3, MW: 294.3

AG490 Cas#133550-30-8.Purity:>98%.Best Price and Quality in the Market!Supplied by DC Chemicals! AG-490 (Tyrphostin B42) is an inhibitor of EGFR, ErbB2 and JAK2 with IC50 of 0.1 μM, 13.5 μM, and ~10 μM, respectively.

Tyrphostin AG490 is a JAK-2 specific inhibitor, which inhibits phosphorylation of EGFR and signal transducer and activator of transcription 3 [STAT-3], and subsequently reduce invasion and adhesion potential of malignant cells. The hematopoietic cancer c-Kit+, Jak-2+ and non hematopoietic tumors c-Kit+, HER-2+, JAK-2+ can be inhibited by the chemosensitizing agent AG490 causing programmed cell death.

For the detailed information about the solubility of AG 490 in water, the solubility of AG 490 in DMSO, the solubility of AG 490 in PBS buffer, the animal experiment of AG 490,the in vivo and in vitro test of AG 490,the cell experiment of AG 490,the IC50 and EC50 of AG 490please contact DC Chemicals.