Monomethyl auristatin E (MMAE, vedotin) supplier-DC Chemicals

DC Chemicals develops a novel ADC compound Monomethyl auristatin E (MMAE, vedotin).

CAS#:474645-27-7
Purity of current batch: 98.98%
Molecular Weight:717.98
Formula:C39H67N5O7

In stock.

Chemical structure:

About:Monomethyl auristatin E (MMAE, vedotin)

Monomethyl auristatin E (MMAE, vedotin) is a very potent anti-mitotic agent that inhibits cell division byblocking the polymerisation of tubulin. Because of its super toxicity, it cannot be used as a drug itself. Inrecent cancer therapy developments, it is linked to a monoclonal antibody (mAb) that recognizes a specific marker expression in cancer cells and directs MMAE to the cancer cells. The linker linking MMAE to the monoclonal antibody is stable in extracellular fluid, but is cleaved by cathepsin once the antibody-drug-conjugate/ADC has bound to the specific cancer cell antigen and entered the cancer cell,thus releasing the toxic MMAE and activating the potent anti-mitotic mechanism.

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